Spider-Man: Friend or Foe is a Spider-Man video game based on the comic book series and Spider-Man movies. The game was released on October 2, 2007.

Spider-Man: Friend or Foe was originally announced via a promotional page on the back of the Spider-Man 3 video game instruction booklet. The teaser stated that the game would be a "A new twist on the legend. A new take on the movies." The game's website shows a few screenshots of the game and the Green Goblin makes an appearance. The game has a very different engine and style as compared to the previous official film tie-ins.

According to the company report, Spider-Man: Friend or Foe is a unique take on the media franchise. Inspired by the movies Spider-Man, Spider-Man 2, and Spider-Man 3, this action/adventure beat 'em up game reinterprets big-screen moments and battles with a humorous twist. Players team up with famous heroes from the Marvel Comics universe to combat villains and then convert them to sidekicks after defeating them in epic boss battles. The game includes a co-op multiplayer mode, as Spider-Man or a sidekick, in locations around the globe, including Tokyo, Egypt, and Nepal.

Spider-Man: Friend or Foe, along with most other games published by Activision that had used the Marvel licence, was de-listed and removed from all digital storefronts on January 1, 2014.