A space flight simulation game is a genre of flight simulator video games that lets players experience space flight. Examples of true simulators which aim at piloting a space craft in a manner that conforms with the laws of nature include Orbiter, Kerbal Space Program and Microsoft Space Simulator.

Space flight games and simulators, at one time popular, had for most of the new millennium been considered a "dead" genre. However, open-source and enthusiast communities managed to produce some working, modern titles (see the free Orbiter Spaceflight Simulator), and 2011's commercially released Kerbal Space Program was notably well-received, even by the aerospace community. Some more recent games, most notably Star Citizen, Elite: Dangerous, and No Mans Sky have brought new attention to the space trading and combat game subgenre.

Some games in the genre have the aim of recreating a realistic portrayal of space flight, involving the calculation of orbits within a more complete physics simulation than pseudo space flight simulators. Others focus on gameplay rather than simulating space flight in all its facets. The realism of the latter games is limited to what the game designer deems to be appropriate for the gameplay, instead of focusing on the realism of moving the spacecraft in space. Some "flight models" use a physics system based on Newtonian physics, but these are usually limited to manoeuvring the craft in its direct environment, and do not take into consideration the orbital calculations that would make such a game a simulator. Most of the pseudo simulators feature faster than light travel.