Sherlock Holmes Versus Jack the Ripper is an adventure game for Microsoft Windows and Xbox 360, developed by Frogwares. It is the fifth game in the Sherlock Holmes series of adventure games developed by Frogwares. The game takes place in the London district of Whitechapel in 1888, the historical site of the Jack the Ripper murders.

Following the remastered version of Sherlock Holmes: The Awakened and Sherlock Holmes versus Arsène Lupin, Sherlock Holmes versus Jack the Ripper offered the ability to play in a third-person perspective in addition to the first-person perspective. The French version of the game was released on April 30, 2009. The English version was released on May 24.